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NUTT, N. CUI, H. Biomedical Simulations Resource, Los Angeles. DEAN, S.

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EDDY, L. FANG, R. LI, A. WU , Optimal design of experiments in pharmaceutical applications, in A. Dmitrienko, C. Chuang-Stein, R.

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HALE, H. KO, J-L. PECK eds. Last accessed 29 February MA, B. HU, W. An approach for identifiability of population pharmacokinetic—pharmacodynamic models. Shaw, J. Development of a postgraduate educational program for pharmacist prescribers in New Zealand. Yeo, T. A randomized pilot study of L-arginine infusion in severe falciparum malaria: Preliminary safety, efficacy and pharmacokinetics. General practitioners' views of pharmacists' current and potential contributions to medication review and prescribing in New Zealand.

Journal of Primary Health Care , 5 3 , A semi-mechanistic red blood cell survival model provides some insight into red blood cell destruction mechanisms.

Physiologically-based Pharmacokinetics Modeling: An Approach for Designing Better Clinical Trials

A bayesian dose-individualization method for warfarin. Clinical Pharmacokinetics , 52 1 , A population pharmacokinetic model for low-dose methotrexate and its polyglutamated metabolites in red blood cells. Clinical Pharmacokinetics , 52 6 , The population pharmacokinetics of allopurinol and oxypurinol in patients with gout. European Journal of Clinical Pharmacology , 69 7 , Toxicon , 61 , Jamsen, K.

Role of pharmacokinetic modeling and simulation in precision dosing of anticancer drugs

A robust design for identification of the Parasite Clearance Estimator. Malaria Journal , 12 , Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology , 51 8 , General practitioners' perceptions of pharmacists' new services in New Zealand. International Journal of Clinical Pharmacy , 34 2 , Vos, F. Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring.

Nephrology , 17 2 , Development and evaluation of a prototype of a novel clotting time test to monitor enoxaparin. Pharmaceutical Research , 29 1 , Comparison of robust criteria for D-optimal designs.

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  6. Journal of Biopharmaceutical Statistics , 22 6 , McGree, J. Adaptive Bayesian compound designs for dose finding studies. Design of pharmacokinetic studies for latent covariates. Population pharmacokinetics and pharmacodynamics of escitalopram in overdose and the effect of activated charcoal. British Journal of Clinical Pharmacology , 73 3 , Evaluation of the pre-posterior distribution of optimized sampling times for the design of pharmacokinetic studies.

    Journal of Biopharmaceutical Statistics , 22 1 , Loke, S. Challenges in integrating a complex systems computer simulation in class: An educational design research. Australasian Journal of Educational Technology , 28 4 , A pharmacokinetic model for the glycation of albumin. Adaptive optimal design for bridging studies with an application to population pharmacokinetic studies.

    Pharmaceutical Research , 29 6 , A generalisation of T-optimality for discriminating between competing models with an application to pharmacokinetic studies. Pharmaceutical Statistics , 11 6 , A general method to determine sampling windows for nonlinear mixed effects models with an application to population pharmacokinetic studies. Pharmaceutical Statistics , 11 4 , A reduction in between subject variability is not mandatory for selecting a new covariate.

    Shen, F. A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose.

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    Clinical Toxicology , 49 7 , Pavan Kumar, V. The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose. British Journal of Clinical Pharmacology , 72 1 , British Journal of Clinical Pharmacology , 71 6 , Evaluation of graphical diagnostics for assessing goodness of fit of logistic regression models.

    SimPharm: How pharmacy students made meaning of a clinical case differently in paper- and simulation-based workshops. British Journal of Educational Technology , 42 5 , Modeling red blood cell survival data.

    Biomarkers, Validation and Pharmacokinetic-Pharmacodynamic Modelling |

    Evaluation of red blood cell labelling methods based on a statistical model for red blood cell survival. Journal of Theoretical Biology , , Coulter, C. Methanol and ethylene glycol acute poisonings: Predictors of mortality. Clinical Toxicology , 49 10 , Joy, J. Prediction of Torsade de Pointes from the QT interval: Analysis of a case series of amisulpride overdoses. Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria.

    Malaria Journal , 10 , Interpreting population pharmacokinetic-pharmacodynamic analyses: A clinical viewpoint. Red blood cell survival RBC in patients on long-term dialysis. Nephrology , 16 Suppl.

    Development of a Bayesian forecasting method for warfarin dose individualisation. Pharmaceutical Research , 28 5 , The influence of dosing time, variable compliance and circadian low-density lipoprotein production on the effect of simvastatin: Simulations from a pharmacokinetic—pharmacodynamic model. Denman, N. Design of experiments for bivariate binary responses modelled by Copula functions.

    Young, S. B Ron Keizer Experiences in applied clinical pharmacometrics: challenges, recommendations, and research opportunities Wednesday B Coffee break, poster and software session I: posters in Group I with poster numbers starting with I- are accompanied by their presenter Wednesday B Chloe Pasin Use of mathematical modeling for optimizing and adapting immunotherapy protocols in HIV-infected patients Wednesday B Mouna Akacha Background on estimands and why are they important?

    Wednesday B Camille Vong Power assessment for hierarchical combination endpoints using joint modelling of repeated time-to-event and time-to-event models versus Finkelstein-Schoenfeld method Wednesday B Yixuan Zou A novel score test-based method for efficient covariate selection in population pharmacokinetic analysis Wednesday B Mats Karlsson Extensive and automatic assumption assessment of pharmacometric models Wednesday C Benjamin Guiastrennec New dosing recommendations for anti-tuberculosis therapy in Indian children Thursday C Jurgen Langenhorst Cause-specific hazard models with markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation Thursday C Gustaf Wellhagen A bounded integer model for rating and composite scale data Thursday C Presentation of Lewis Sheiner student session awards Thursday C Phyllis Chan Assessment of a model to correlate early tumor size response to overall survival in relapsed or refractory diffuse large B cell lymphoma patients Thursday C Benjamin Ribba Drug response variability and optimal dosing in immuno-oncology Thursday C Rukmini Kumar Predicting response and identifying responders to combination cancer immunotherapy in melanoma using Quantitative Systems Pharmacology QSP models Thursday C Hanna Silber Baumann PKPD analysis of soluble CD25 to characterize the concentration-effect relationship observed following the administration of Cergutuzumab Amunaleukin, a targeted immunocytokine for cancer immunotherapy Thursday D David Ternant Population and Bayesian kinetic modelling of necrosis biomarkers to assess the effect of conditioning therapies on infarct size Friday D Chihiro Hasegawa Simplification of multi-scale systems models for data-driven analyses: what has progressed in these 5 years?

    Friday D Sulav Duwal A multiscale systems pharmacology framework to predict drug-class specific prophylactic efficacy of antivirals against HIV Friday D Vincent Madelain Ebola viral dynamics in nonhuman primates: insights into virus immuno-pathogenesis and antiviral strategies Friday I Johannes Schropp Characterization of bispecific antibodies and the ternary complex including an optimal dosing strategy Wednesday I Pascal Schulthess Frequency-domain derived optimisation of cell cycle specific cancer treatment Wednesday I Malte Selch Larsen Impact of trial designs, study conditions and statistical methods on the estimation of drug potency and power in clinical trials of haemophilia with inhibitors Wednesday I Dmitry Shchelokov A semi-mechanistic model of targeted therapy for melanoma Wednesday I Christian Siebel Consensus on doxorubicin dosing in infants and children: pharmacokinetic simulations and Delphi process Wednesday I Alena Simalatsar Personalised delivery rate computation for intravenously administered anesthetic using Kalman filter Wednesday I Tom Snowden A comparison of two model reduction methodologies for a QSP bone biology system with denosumab dosing.